Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation
نویسندگان
چکیده
Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation Erik J. Eide, Margaret F. Woolf, Heeseog Kang, Peter Woolf, William Hurst, Fernando Camacho, Erica L. Vielhaber, Andrew Giovanni, and David M. Virshup* Department of Oncological Sciences and the Center for Children, Huntsman Cancer Institute, and Division of Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan; and Aventis Pharmaceuticals, Bridgewater, New Jersey
منابع مشابه
Protein phosphatase 1 regulates the stability of the circadian protein PER2.
The circadian clock is regulated by a transcription/translation negative feedback loop. A key negative regulator of circadian rhythm in mammals is the PER2 (mammalian PERIOD 2) protein. Its daily degradation at the end of the night accompanies de-repression of transcription. CKI (casein kinase I ) has been identified as the kinase that phosphorylates PER2, targeting it for ubiquitin-mediated pr...
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